Publications:
Book Chapters or Reviews:
11. Nairn, A.V. and Moremen, K. W. (2015) Glycotranscriptomics in Glycoscience: Biology and Medicine (N. Taniguchi, T. Endo, G. Hart, P. Seeberger, C.-H. Wang eds.) Springer-Verlag, Tokyo, pp. 1475-1482 [PMCID not applicable]
10. Nairn, A.V. and Moremen, K. W. (2014) Mannosyl-oligosaccharide glucosidase (Glucosidase I, MOGS) in Handbook of Glycosyltransferases and Related Genes, 2nd edition (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, and T. Angata, eds.) Springer-Verlag, Tokyo, pp. 1273-1282. [PMCID not applicable]
9. Moremen, K. W. and Nairn, A.V. (2014) Mannosidase, alpha, class 2a1 (MAN2A1, Golgi alpha--mannosidase II) in Handbook of Glycosyltransferases and Related Genes, 2nd edition (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, and T. Angata, eds.) Springer-Verlag, Tokyo, pp. 1313-1326. [PMCID not applicable]
8. Moremen, K. W. and Nairn, A.V. (2014) Mannosidase, alpha, class 1 (MAN1A1 (Golgi alpha--mannnosidase IA), Man1A2 (Golgi a-mannosidase IB), MAN1B1(ER a-mannosidase I), MAN1C1 (Golgi a-mannosidase IC ) in Handbook of Glycosyltransferases and Related Genes, 2nd edition (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, and T. Angata, eds.) Springer-Verlag, Tokyo, pp. 1297-1312. [PMCID not applicable]
7. Nairn, A.V. and Moremen, K. W. (2014) Glucosidase, alpha neutral AB; glucosidase II subunit beta (GANAB, PRKCSH, alpha-glucosidase II) in Handbook of Glycosyltransferases and Related Genes, 2nd edition (N. Taniguchi, K. Honke, M. Fukuda, H. Narimatsu, Y. Yamaguchi, and T. Angata, eds.) Springer-Verlag, Tokyo, pp. 1283-1295 [PMCID not applicable]
6. Nairn, A.V. and Moremen, K.W. (2009) Glycotranscriptomics. In Handbook of Glycomics (J.M. Pierce and R.D. Cummings eds.) Academic Press/Elsevier, pp. 81-136 [PMCID not applicable]
5. Moremen, K. W. (2002) a-Mannosidase II in Handbook of Glycosyltransferases and Related Genes, (N. Taniguchi and M. Fukuda, eds.) Springer-Verlag, Tokyo, pp. 600-606
4. Moremen, K. W. (2000) a-Mannosidases in Asparagine-linked Oligosaccharide Processing and Catabolism. in Oligosaccharides in Chemistry and Biology: A Comprehensive Handbook, Vol. II, Part 1 (B. Ernst, G. Hart, and P. Sinay, eds.) Wiley and Sons Publishers, New York, 81-117.
3. Trimble, R. B., Moremen, K.W., and Herscovics, A. (1994) Mannosidases of the Golgi Apparatus. in Guidebook to the Secretory Pathway (J. A. Rothblatt, T. Stevens, and P. Novick eds.) Sambrook and Tooze Scientific Publishers. pp. 185-188.
2. Trimble, R. B., Moremen, K.W., and Herscovics, A. (1994) N-glycan processing in the endoplasmic reticulum in Guidebook to the Secretory Pathway (J. A. Rothblatt, T. Stevens, and P. Novick eds.) Sambrook and Tooze Scientific Publishers. pp. 100-104.
1. Moremen, K. W. and Touster, O. (1987) Mannosidases in Mammalian Glycoprotein Processing. in Protein Transfer and Organelle Biogenesis (R.C. Das and P.W. Robbins eds.) Academic Press, pp. 209-240.
Journal Articles (peer reviewed):
2020160. Deng, X., Yao, X., Miller, C., Hamelberg, D., Kirberger, M., Moremen, K.W., Hu, J., and Yang, J.J. (2020) Structural Mechanism of Cooperative Regulation of Calcium Sensing Receptor Mediated Cellular Signaling. Curr. Opinion Physiol. in press.
159. Rogals, M.J., Yang, J.-Y., Williams, R.V., Moremen, K.W., Amster, I.J., and Prestegard, J.H. (2020) Sparse Isotope Labeling for NMR of Glycoproteins using 13C-Glucose. Glycobiology in press
158. Petry, J., Rahmoller, J., Duhring, L., Lilienthal, G.-L., Lehrian, S., Buhre, J.-S., Bartsch, Y.C. Epp, A., Hanna B. Lunding, H.B., Moremen, K.W., Leliavski, A., and Ehlers M., (2019) Enriched blood IgG sialylation attenuated IgG-mediated and IgG-controlled-IgE-mediated allergic reactions J. Allergy Clin. Immunol. In press [PMID: 32603664; PMC in process]
157. Prabhakar, P., Wang, H.-T., Smith, P.J., Yang, J.-Y., Pena, M.J., Barnes, W.J., Moremen, K.W., and Urbanowicz, B.R. (2020) Methods for expression of plant glycosyltransferases for biochemistry and structural biology. Meth. Cell Biol. in press
156. Ruprecht, C., Bartetzko, M.P., Senf, D., Lakhina, A., Smith, P.J., Soto, M., Oh, H., Yang, J.-Y., Chapla, D., Varon Silva, D., Clausen, M.H., Hahn, M.G., Moremen, K.W., Urbanowicz, B.R., and Pfrengle, F. (2020) A Glycan Array-Based Assay for the Identification and Characterization of Plant Glycosyltransferases Angewandte Chemie in press. [PMID: 32396713; PMC7383710]
155. Shajahan, A., Supekar, N.T., Chapla, D., Heiss, C., Moremen, K.W., Azadi, P. (2020) Simplifying Glycan Profiling through a High-Throughput Micropermethylation Strategy. SLAS Technol. in press doi: 10.1177/2472630320912929.[PMID: 32364434; PMCID in progress]
154. Lunin, V.V, Wang, H.-T., Bharadwaj, V.S., Alahuhta, M., Pena, M.J., Yang, J.-Y.,Archer-Hartmann, S.A., Azadi, P., Himmel, M.E., Moremen, K.W., York, Y.S., Bomble, Y.J., and Urbanowicz, B. (2020) Molecular mechanism of polysaccharide acetylation by the AtXOAT1 xylan O-acetyltransferase. Plant Cell 32: 2367-2382. [PMID: 32354790; PMC7346548]
153. Hong, S., Grande, G., Yu, C., Chapla, D.G., Reigh, N., Yang, Y., Izumori, K., Moremen, K.W., Xie, J., and Wu, P. (2019) hFUT1-based live cell assay to profile ?1-2-fucosides-enhanced influenza A virus infection ACS Chem Biol. 15: 819-823 [PMID: 32271008; PMC in process]
152. Taujale, R., Venkat, A., Huang, L.-C., Yeung, W., Rasheed, K., Edison, A.S., Moremen, K.W., and Kannan, N. (2019) Deep evolutionary analysis reveals the design principles of fold A glycosyltransferases eLife 9: e54532. [PMID: 32234211; PMC7185993]
151. Sheikh, M.O., Venzke, D., Anderson, M.E., Yoshida-Moriguchi, T., Glushka, J.N., Nairn, A.V., Galizzi, M., Moremen, K.W., Campbell, K.P., and Wells, L. (2020) HNK-1 Sulfotransferase modulates ?-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan. Glycobiology DOI: 10.1093/glycob/cwaa024 in press. [PMID: 32149355; PMC in process]
150. Li, Z., Kitov, P., Kitova, E., Mozenah, F., Rodrigues, E., Chapla, D., Moremen, K., Macauley, M., Klassen, J. (2019) CUPRA-ZYME: A novel assay for measuring carbohydrate-active enzyme activities, pathways and substrate specificities. Anal. Chem. in press.
149. Saeui, C.T., Cho, K.-C., Dharmarha, V., Nairn, A.V., Galizzi, M., Shah, S.R., Gowda, P., Park, M., Austin, M., Clarke, A., Cai, E., Buettner, M.J., Ariss, R., Moremen, K.W., Zhang, H., and Yarema, K.J. (2019) Cell Line-, Protein-, and Sialoglycosite-Specific Control of Flux-based Sialylation in Human Breast Cells: Implications for Cancer Progression. Front Chem in press.
2019
148. Moremen, K.W., and Haltiwanger R.S. (2019) Emerging structural insights into glycosyltransferase-mediated synthesis of glycans. Nature Chem. Biol. 15: 853-864 [PMID: 31427814; PMC6820136].
147. t'Hart, I., Li, T., Wolfert, M.A., Wang, S., Moremen, K.W., and Boons, G.-J. (2019) Chemoenzymatic synthesis of the oligosaccharide of the tumor-associated antigen disialosyl globopentaosylceramide Org and Biomol Chem 17: 7304-7308 [PMID: 31339142; PMC6852662]
146. Hong, S., Sahai-Hernandez, P., Chapla, D.G., Moremen, K.W., Traver, D., and Wu, P. (2019) Direct Visualization of Live Zebrafish Glycan via Single-step Metabolic Labeling with Fluorophore-tagged Nucleotide Sugars. Angew Chem Int Ed Engl 58: 14327-14333 [PMID: 31295389; PMC6820142]
145. Steentoft, C., Yang, Z., Wang, S., Ju, T., Vester-Christensen, M.B., Festari, M.F., King-Smith, S.L., Moremen, K.W., Bohse Larsen, I.S., Knak Goth, C., Schjoldager, K.T., Hansen, L., Bennett, E.P., Mandel, U., and Narimatsu, Y. (2019) A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-Glycosylation. Glycobiology 29: 645-656 [PMID: 31172184; PMC6704369]
144. Chalmers, G., Eletsky, A., Morris, L., Yang, J.-Y., Tian, F., Woods, R.J., Moremen, K.W., and Prestegard J.H. (2019) NMR Resonance Assignment Methodology: Characterizing Large Sparsely Labeled Glycoproteins J. Mol. Biol. 431: 2369-2382. [PMID:31034888; PMC6554063]
143. Williams, R.V., Yang, J.-Y., Moremen, K.W., Amster, I.J., and Prestegard, J.H. (2019) Measurement of Residual Dipolar Couplings in Methyl Groups via Carbon Detection J Biomol NMR 73: 191-198. [PMID:31041649; PMCID in progress]
142. Nasirikenari, M., Punch, P., Lugade, A., Neelamegham, S., Gao, Z., Moremen, K.W., Bogner, P.N., Thanavala, Y., and Lau, J.T.Y. (2019) Acute lung inflammation is mitigated by systemic infusion of a recombinant sialyltransferase Front Immunol 10:48. [PMID:30778346; PMC6369197]
141. Chinoy, Z.S., Bodineau, C., Favre, C., Moremen, K.W., Duran, R.V., and Friscourt, F. (2019) Selective Engineering of Linkage Specific alpha-2,6-N-Linked Sialoproteins using Sydnone-Modified Sialic Acid Bioorthogonal Reporters Angew Chem Int Ed Engl 58: 4281-4285 [PMID:30706985; PMC6450558]
140. Li, T., Liu, L., Wei, N., Yang, J.-Y. Chapla, D.G., Moremen, K.W., and Boons G.J. (2019) An automation platform for the enzyme-mediated assembly of complex oligosaccharides Nature Chem. 11: 229-236 [PMID:30792508; PMC6399472]
139. Li, J., Chen, M., Liu, Z., Zhang, L., Felding, B.H., Moremen, K.W., Lauvau, G., Abadier, M., Ley, K., Wu, P. (2019) A Single-step Chemoenzymatic Reaction for the Construction of Antibody-cell Conjugates ACS Central Science 4:1633-1641 [PMID:30648147; PMC6311947]
138. Liu, L., Prudden, A.R., Capicciotti, C.J., Bosman, G.P., Yang, J.Y., Chapla, D.G., Moremen, K.W., and Boons, G.J. (2019) Streamlining the Chemoenzymatic Synthesis of Complex N-Glycans by a Stop and Go Strategy. Nature Chem. 11:161-169 [PMID:30532014; PMC6347513]
2018
137. Qiu, H, Shi, S., Yue, J., Xin, M., Nairn, A.V., Lin, L., Liu, X., Li, G., Archer-Hartmann, S.A., Dela Rosa, M., Galizzi, M., Wang, S., Zhang, F., Azadi, P., van Kuppevelt, T.H., Cardoso, W.V., Kimata, K., Ai, X., Moremen, K.W., Esko, J., Linhardt, R.J., and Wang, L. (2018) A mutant cell library for systematic analysis of heparan sulfate. Nature Meth. 15: 889-899 [PMID:30377379; PMC6214364]
136. Muchero, W., Sondreli, K.L., Chen, J.-G., Urbanowicz, B.R., Zhang, J., Singan, V., Yang, Y., Brueggeman, R.S., Franco-Coronado, J., Abraham, N., Yang, J.-Y., Moremen, K.W., Weisberg, A.J., Chang, J.H., Lindquist, E., Berry, K., Ranjan, P., Jawdy, S., Schmutz, J., Tuskan, G.A., LeBoldus, J.M. (2018) Association mapping, transcriptomics, and transient expression identify candidate genes mediating plant-pathogen interactions in a tree. Proc. Natl. Acad. Sci. USA 115: 11573-11578 [PMID:30337484; PMC6233113]
135. Amos, R.A., Pattathil, S., Yang, J.Y., Atmodjo, M.A., Urbanowicz, B.R., Moremen, K.W., Mohnen, D. (2018) A two-phase model for the non-processive biosynthesis of homoglacturonan polysaccharides by the GAUT1:GAUT7 complex. J. Biol. Chem. 293: 19047-19063 [PMID:30327429; PMC6295712]
134. Voiniciuc, C., Engle, K., Gunl, M., Dieluweit, S., Heinrich-Wilhelm Schmidt, M., Yang, J.-Y., Moremen, K.W., Mohnen, D., and Usadel B. (2018) Identification of Key Enzymes for Pectin Synthesis in Arabidopsis Seed Mucilage. Plant Physiol 178: 1045-1064 [PMID:30228108; PMC6236597]
133. Thieker, D., Xu, Y., Chapla, D., Nora, C., Qiu, H., Felix, T., Wang, L., Moremen, K.W., Liu, J., Esko, J., and Woods, R.J. (2018) Downstream products are potent inhibitors of the heparan sulfate 2-O-sulfotransferase Scientific Reports 8, 11823 [PMID:30087361; PMC6081452].
132. Moure, M.J., Eletsky, A., Gao, Q., Morris, L. Yang, J.Y., Chapla, D., Zhao, Y., Zong, C., Boons, G.J., Moremen, K.W., and Prestegard, J.H. (2018) Paramagnetic Tags for Glycosylation sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1. ACS Chem Biol 13: 2560-2567 [PMID:30063822, PMC6161356]
131. Yu, S.H., Zhao, P., Prabakhar, P. K., Sun, T., Beedle, A., Boons, G.J., Moremen, K.W., Wells, L., Steet, R. (2018) Defective mucin-type glycosylation on ?-dystroglycan in COG-deficient cells increases its susceptibility to bacterial proteases J. Biol. Chem. 293, 14534-14544. [PMID:30049793, PMC6139567]
130. Saeui, C.T., Nairn, A.V., Galizzi, M., Douville, C., Gowda, P., Park, M., Dharma, V., Shah, S., Clark, A., Austin, M., Moremen, K.W., and Yarema, K.J. (2018) Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes. PLOS One 13: e0195812 [PMID:29847599; PMC5976204]
129. Kadirvelraj, R., Yang, J.-Y., Sanders, J.H., Liu, L., Ramiah, A., Prabhakar, P.K., Boons, G.-J., Wood, Z.A., and Moremen, K.W. (2018) Human N-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite. Proc. Natl. Acad. Sci. USA, 115:4637-4642. [PMID:29666272; PMC5939069]
128. Gao, Q., Yang, J.Y., Moremen, K.W., Flanagan, J.G., and Prestegard, J.H. (2018) Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2. Biochemistry 57, 2189-2199. [PMID: 29570275; PMC6015444]
127. Lopez Aguilar, A., Meng, L., Hou, X., Li, W., Moremen, K.W. Wu, P. (2018) Sialyltransferase-based Chemoenzymatic Histology for the Detection of N- and O- glycans. Bioconjugate Chem. 29, 1231-1239. [PMID:29569918; PMC5972038]
126. Zhao, Y., Yang, J.Y., Thieker, D.F., Xu, Y., Zong, C., Boons, G.-J., Liu, J., Woods, R.J., Moremen, K.W., Amster. I.J. (2018) Traveling wave ion mobility spectrometry (TWIMS) study of the Robo1-heparan sulfate interaction. J. Amer. Soc. Mass Spectrom 6:1153-1165 [PMID:29520710; PMC6004239]
125. Briard, J.G., Jiang, H., Moremen, K.W., Macauley, M.S., and Wu, P. (2018) Cell-Based Glycan Arrays for Probing Glycan-Glycan Binding Protein Interactions. Nature Commun. 9: 880 [PMID:29491407; PMC5830402]
124. Jensen, J.K., Busse-Wicher, M., Poulsen, C.P., Fangel, J.U., Smith, P.J., Yang, J.-Y., Pena, M.-J., Dinesen, M.H., Martens, H.J., Melkonian, M., Wong, G.K, Moremen, K.W., Wilkerson, C.G., Scheller, H.V., Dupree, P., Ulvskov, P., Urbanowicz, B.R., and Harholt, J. (2018) Identification of an algal xylan synthase KfXYS1 proves that there is functional orthology between algal and plant cell wall biosynthesis. New Phytologist. 218, 1049-1060. [PMID:29460505; PMC5902652]
123. Rouhanifard, S.H., Aguilar, A.L., Meng, L., Izumori, K., Moremen, K.W., and Wu, P. (2018) Engineered glycocalyx regulates stem cell proliferation in crypt organoids. Cell Chem. Biol. 25, 1-8. [PMID:29429899; PMC5910180]
122. Kudelka, M., Nairn, A.V., Sardar, M.Y., Sun, X., Chaikof, E.L., Moremen, K.W., and Cummings, R.D. (2018) Isotopic Labeling with Cellular O-glycome Reporter/Amplification (ICORA) for Comparative O-glycomics of Cultured Cells. Glycobiology, 28, 214-222. [PMID:29390058; PMC6067123]
121. Jiang, H., Lopez-Aguilar, A., Meng, L., Gao, Z., Liu, Y., Tian, X., Yu, G., Ovryn. B., Moremen, K.W., Wu, P. (2018) Modulating Cell-Surface Receptor Signaling and Ion Channel Functions by In Situ Glycan Editing. Angew Chem Int Ed Engl. 57, 967-971. [PMID:29292859; PMC5779621]
120. Moremen, K.W., Ramiah, A., Stuart, M., Steel, J., Meng, L., Forouhar, F., Moniz, H.A., Gahlay, G., Gao, Z., Chapla, D., Wang, S., Yang, J.-Y., Prabahkar, P. K., Johnson, R., dela Rosa, M., Geisler, C., Nairn, A.V., Wu, S.-C., Tong, L., Gilbert, H.J., LaBaer, J., and Jarvis, D.L. (2018) Expression system for structural and functional studies of human glycosylation enzymes. Nature Chem. Biol. 14, 156-162 [PMID:29251719; PMC5774587]
119. Epp, A., Hobusch, J., Bartsch, Y., Eschweiler, S., Mobs, C., Hall, A., Morris, S.C., Petzold, D., Lilienthal, G.-M., Engellenner, C., Bitterling,J., Petry,J., Rahmoller,R., Collin, M., Moremen, K.W., Strait, R.T., Blanchard, V., Petersen, A., Gemoll, T., Habermann, J.K., Petersen, F., Nandy, A., Kahlert, H., Hertl, M., Pfutzner, W., Jappe, U., Finkelman, F.D., and Ehlers, M. (2018) Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions. J. Allergy Clin. Immunol. 141, 399-402. [PMID:28728998; PMC5758435]
2017
118. Benedetti, E., Pu?i?-Bakovi?, M., Keser, T., Wahl, A., Hassinen, H., Trbojevi? Akma?i? , I., Vila, M., Razdorov , G., Stambuk , J., Klari?,L., Ugrina, I., Selman, M., Wuhrer, M., Rudan, I., Polasek, O., Caroline Hayward, C., Grallert, H., Strauch, K., Peters, A., Meitinger, T., Gieger, C., Yang, J.-Y., Lui, L., Boons, G.-J., Kellokumpu , S., Moremen, K.W., Bovin, N., Theis, F.J., Lauc, G., and Krumsiek, J. (2017) Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway. Nat Commun. 8, 1483. [PMID:29440641; PMC5811429]
117. Tuomivaara, S.T., Schliekelman, P., Nairn, A.V., Moremen, K.W., and York W.S. (2017) RElative QUantitation Inferred by Evaluating Mixtures (REQUIEM). Analytica Chim Acta 993, 22-37 [PMID: 29078952; PMC5735846]
116. Tong, W., Dwyer, C.A., Thacker, B.E., Glass, Brown, J.R., Hamil, K., Moremen, K.W., Sarrazin, S., Gordts, P.L.S.M., Dozier, L., Patrick, G.N., Tor, Y., and Esko, J.D. (2017) Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain. Molecular Therapy 25, 2743-2752. [PMID 28958576; PMC5768556]
115. Urbanowicz, B.R., Bharadwaj, V.S., Alahuhta, M., Pena, M.J., Lunin, V.V., Bomble, Y.J., Wang, S., Yang, J.-Y., Tuomivaara, S., Himmel, M.E., Moremen, K.W., York, W.S., and Crowley, M.F. (2017) Structural, Mutagenic and In Silico studies of Xyloglucan Fucosylation in Arabidopsis thaliana Suggest a Water-Mediated Mechanism. Plant J. 91: 931-949. [PMID:28670741; PMC5735850]
114. Hanes, M.S., Moremen, K.W., Cummings, R.D. (2017) Biochemical characterization of functional domains of the chaperone Cosmc. PLOS One, 12:e0180242. [PMID:28665962; PMC5493369]
113. Prudden, A.R., Liu, L., Capicciotti, C.J., Wolfert, M.A., Wang, S., Gao, Z., Meng, L., Moremen, K.W., Boons, G.-J. (2017) Synthesis of asymmetrical multi-antennary human milk oligosaccharides. Proc. Natl. Acad. Sci. USA 114, 6954-6959 [PMID:28630345; PMC5502611]
112. Gao, Q., Chalmers, G.R., Moremen, K.W., and Prestegard, J.H. (2017) NMR Assignments of Sparsely Labeled Proteins Using a Genetic Algorithm J. Biomolecular NMR. 67, 283-294. [PMID:28289927; PMC5434516]
111. Sheikh, M.O., Halmo, S.M., Patel, S., Middleton, D., Takeuchi, H., Schafer, C.M., West, C.M., Haltiwanger, R.S., Avci, F.Y., Moremen, K.W., and Wells, L. (2017) Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases Glycobiology, 27, 206-212. [PMID:28177478; PMC5789813]
110. Guo, H., Zhang, B., Nairn, A., Nagy, T., Moremen, K.W., Buckhaults, P., and Pierce, M. (2017) O-GlcNAc expression levels epigenetically regulate colon cancer tumorigenesis by affecting the cancer stem cell compartment via modulating expression of transcriptional factor MYBL1. J. Biol. Chem. 292, 4123-4137. [PMID:28096468; PMC5354504]
109. Halmo, S.M., Singh, D., Patel, S., Wang, S., Edlin, E., Boons, G.J., Moremen, K.W., Live, D.H., and Wells, L. (2017) Protein O-linked mannose ?-1,4-N-acetylglucosaminyltransferase 2 (POMGNT2) is a Gatekeeper Enzyme for Functional Glycosylation of ?-Dystroglycan. J. Biol. Chem. 292, 2101-2109. [PMID:27932460; PMC5313085]
2016
108. Xiang, Y., Karaveg, K., and Moremen, K.W. (2016) Substrate recognition and catalysis by GH47 a-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc. Natl. Acad. Sci. USA, 113: E7890-E7899. [PMID:27856750] [PMC5150396]
107. Li, T., Huang, M., Liu, L., Wang, S., Moremen, K.W., Boons, G.J. (2016) Divergent Chemoenzymatic Synthesis of Asymmetrical Core Fucosylated and Core-Unmodified N-Glycans. Chemistry 22, 18742-18746 [PMID:27798819] [ PMC5442444]
106. Aoki-Kinoshita K, Agravat S, Aoki NP, Arpinar S, Cummings RD, Fujita A, Fujita N, Hart GM, Haslam SM, Kawasaki T, Matsubara M, Moremen KW, Okuda S, Pierce M, Ranzinger R, Shikanai T, Shinmachi D, Solovieva E, Suzuki Y, Tsuchiya S, Yamada I, York WS, Zaia J, Narimatsu H. (2016) GlyTouCan 1.0--The international glycan structure repository. Nucleic Acids Res. 44:D1237-42. [PMID 26476458] [PMC4702779]
105. Gao, Q., Chen, C.Y., Zong, C., Wang, S., Morris, L.C., Boons, G.-J., Moremen, K.W., and Prestegard J.H. (2016) Structural Aspects of Heparan Sulfate Binding to Robo1-D12. ACS Chemical Biology 11:3106-3113. [PMID:27653286] [PMC5148660]
104. Zong, C., Huang, R., Condac, E., Chiu, Y., Xiao, W., Li, X., Lu, W, Ishihara, M., Wang, S., Ramiah, A., Stickney, M., Azadi, P., Amster, I.J., Moremen, K.W., Wang, L., Sharp, J.S., Boons, G.J. (2016) Integrated Approach to Identify Heparan Sulfate Ligand Requirements of Robo1. J Am Chem Soc. 138:13059-13067. [PMID:27611601] [PMC5068570]
103. Sun, T., Yu, S., Zhao, P., Meng, L., Moremen, K.W., Wells, L., Steet, R., and Boons, G.-J. (2016) A One-step Selective Exo-enzymatic Labeling (SEEL) Strategy for the Biotinylation and Identification of Glycoproteins of Living Cells. J Am Chem Soc. 138, 11575-82 [PMID:27541995] [PMC5067740]
102. Zhuo,Y., Yang, J.-Y., Moremen, K.W., and Prestegard, J. (2016) Glycosylation alters dimerization properties of a cell-surface signaling protein, CEACAM1. J. Biol. Chem. 291, 20085-95 [PMID:27471271] [PMC5025693]
101. Deligny, A., Dierker, T.,Dagalv, A., Lundequist, A., Eriksson, I., Nairn, A.V., Moremen, K.W., Merry, C.R.L., Kjellen, L. (2016) NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length. J. Biol. Chem. 291:18600-7 (paper of the week) [PMID:27387504] [PMC5009238]
100. Zhang, C, Zhang, T., Zou, J., Miller, C.J., Gorkhali, R., Yang, J.-Y., Schilmiller, A., Wang, S., Huang, K., Brown, E.M., Moremen, K.W., Hu, J., and Yang, J.J. (2016) Structural Basis for Regulation of Human Calcium-Sensing Receptor by Magnesium Ions and an Unexpected Tryptophan Derivative Co-agonist Science Advances, 2: e1600241 [PMID:27386547] [PMC4928972]
99. McMorran, B., McCarthy, F., Gibbs, E., Pang, M., Marshall. J., Nairn, A., Moremen, K.W., Crosbie-Watson, R., Baum. L. (2016) Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx. Glycobiology, 26, 1120-1132 [PMID:27236198] [PMCID5241718]
98. Praissman, J.L., Willer, T., Sheikh, M.O., Toi, A., Chitayat, D., Lin, Y.Y., Lee, H., Stalnkaker, S., Wang, S., Prabhakar, P, Nelson, S.F., Stemple D.L., Moore, S.A., Moremen, K.W., Campbell, K.P., and Wells. L. (2016) The Functional O-Mannose Glycan on ?-Dystroglycan Contains a Phospho-ribitol Primed for Matriglycan Addition. eLife, 5: e14473 [PMID:27130732] [PMC4924997]
97. Berger, R., Sun, Y.H., Kulik, M., Lee, J.K., Nairn, A., Moremen, K.W., Pierce, M. and Dalton. S. (2016) ST8SIA4-dependent polysialylation is a part of a developmental program required for germ layer formation from human pluripotent stem cells. Stem Cells. 34:1742-52 [PMID:27074314] [PMCID: PMC4931981]
96. Yu SH, Zhao P, Sun T, Gao Z, Moremen KW, Boons GJ, Wells L, Steet R. (2016) Selective exo-enzymatic labeling detects increased cell surface sialoglycoprotein expression upon megakaryocytic differentiation. J. Biol. Chem. 291:3982-9 [PMID: 26733198] [PMC4759176]
95 Revoredo, L., Wang, S., Bennett, E.P., Clausen, H., Moremen, K.W., Jarvis, D.L., Ten Hagen, K., Tabak, L. A., and Gerken, T.A. (2016) Mucin Type O-Glycosylation is Controlled by Short and Long Range Glycopeptide Substrate Recognition that Varies Among Members of the Polypeptide GalNAc Transferase (ppGalNAc-T) Family. Glycobiology 26: 360-76. [PMID: 26610890] [PMC4767052]
2015
94. Subedi, G.P., Moniz, H., Johnson, R.W., Moremen, K.W., and Barb, A.W. (2015) High yield expression of recombinant human proteins with the transient transfection of HEK293 cells in suspension. J. Vis. Exp. 106:e53568 [PMID: 26779721] [PMC4780855]
93. Zhou, T., Frabutt, D.A., Moremen, K.W., and Zheng, Y.-H. (2015) ERManI is required for HIV-1 envelope glycoprotein degradation via endoplasmic reticulum-associated protein degradation pathway. J. Biol. Chem. 290:22184-92. [PMID26205822] [PMC4571969]
92. Magalhaes, A., Marcos-Pinto, R., Nairn, A.V., dela Rosa, M., Ferreira, R.M., Junqueira-Neto, S., Freitas, D., Gomes, J., Oliveira, P., Santos, M.R., Marcos, N.T., Xiaogang, W., Figueiredo, C., Oliveira, C., Dinis-Ribeiro, M., Carneiro, Moremen, K.W., David, L., Reis C.A. (2015) Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathways Biochem. Biophys. Acta, 1852:1928-1939 [PMID:26144047] [PMC4638172]
91. Bello,C., Wang, S., Meng, L., Moremen, K.W., and Becker, C.F.W. (2015) A PEGylated Photocleavable Auxiliary Mediates the Site-Specific Glycosylation and Native Chemical Ligation of Peptides. Angew Chem Int Ed Engl. 54:7711-5 [PMID 25980981] [PMC4524672]
90. Li Z, Moniz HA, Wang, S., Ramiah A, Zhang, F. Moremen KW, Linhardt, R.J., and Sharp J.S. (2015) High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo1-Heparin Binding Interface. J. Biol. Chem. 290:10729-40. [PMID 25752613] [PMC4409239]
2014
89. Zhang, C., Zhuo, Y., Moniz, H.A., Wang, S., Moremen, K.W., Prestegard, J.H., Brown, E., Yang, J.J. (2014) Direct Determination of Multiple Ligand Interactions with the Extracellular Domain of the Calcium Sensing Receptor. J. Biol. Chem. 289: 33529-42 [PMID 25305020] [PMC4246106]
88. Praissman, J.L., Live, D.H., Wang, S., Ramiah, A., Moremen, K.W., and Wells L. (2014) B4GAT1 is the Priming Enzyme for the LARGE-dependent Functional Glycosylation of a-Dystroglycan. eLife, 3, e03943. [PMID 25279697] [PMC4227051]
87 Urbanowicz, B., Pena, M.J., Moniz, H.A., Moremen, K.W., York, W.S. (2014) Two Arabidopsis Proteins Synthesize Acetylated Xylan in Vitro, Plant J. 80, 197-206 [PMID 25141999] [PMC4184958]
86. Zhang, F., Moniz, H.A., Walcott, B., Moremen, K.W., Wang, L., and Linhardt, R.J. (2014) Probing the impact of GFP tagging on Robo1-heparin interaction, Glycoconj J., 4, 299-307. [PMID:24748467] [PMC4118743]
85 Prestegard, J.H., Agard, D.A., Moremen, K.W., Lavery, L.A., Morris, L.C., Pederson, K. (2014) Sparse Labeling of Proteins: Structural Characterization from Long Range Constraints. J. Mag. Res., 241, 32-40 [PMID:24656078] [PMC3964372]
84. Gasimli, L., Hickey, A.M., Yang, B., Li, G., Dela Rosa, M., Nairn, A.V., Kulik, M.J., Dordick, J.S., Moremen, K.W., Dalton, S., Linhardt, R.J. (2014) Changes in glycosaminoglycan structure on differentiation of human embryonic stem cells towards mesoderm and endoderm lineages. Biochim. Biophys. Acta 1840, 1993-2003 [PMID:24412195] [PMC4004645]
83 Zhang, B., Xiao, W., Qiu, H., Zhang, F., Moniz, H., Jaworski, A., Condac, E. Gutierrez-Sanchez, G., Heiss, C., Clugston, R., Azadi, P., Greer, J.J., Bergmann, C., Moremen, K.W. Li, D.Y., Linhardt, R., Esko, J.D., Wang, L., (2014) Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J. Clin. Invest.124, 209-221. [PMID:24355925] [PMC3871243]
2013
82. Mbua, N.E., Li, X., Heather R. Flanagan-Steet, H.R., Meng, L., Moremen, K.W., Wolfert, M.A., Steet, R., and Geert-Jan Boons, G.-J. (2013) Selective Exo-Enzymatic Labeling (SEEL) of N-Glycans of Living Cells by Recombinant ST6Gal I. Angewandte Chem Int. Ed. Engl., 52, 13012-5. [PMID:24129959] [PMC3869382]
81. Zhang, F., Moniz, H., Walcott, B., Moremen, K., Linhardt, R.J., Wang, L. (2013) Characterization of the Interaction between Robo1 and Heparin and other Glycosaminoglycans. Biochimie, 95, 2345-53. [PMID:23994753] [PMC3871176]
80. Meng, L., Forouhar, F., Thieker, D., Gao, Z., Ramiah, A., Moniz, H., Xiang, Y., Seetharaman, J., Milaninia, S., Su, M., Bridger, R., Veillon, l., Azadi, P., Kornhaber, G., Wells, L., Montelione, G. T., Woods, R.J., Tong, L., and Moremen. K.W. (2013) Enzymatic basis for N-glycan sialylation: structure of rat ?2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. J. Biol. Chem. 288, 34680-98 [PMID 24155237] [PMC3843080]
79. Natunen, S., Lampinen, M., Suila, H., Ritamo, I., Pitkanen, V., Nairn, A.V., Rabina, J., Laitinen, S., Moremen, K.W., Reutter, W., Valmu, L. (2013) Metabolic glycoengineering of mesenchymal stromal cells with N-propanoylmannosamine. Glycobiology, 23, 1004-12 [PMID 23708401] [PMC3695754]
78. Gerken, T., Revoredo, L., Thome, J.J.C., Tabak, L.A., Vester-Christensen, M.B., Clausen, H., Gahlay, G.K., Jarvis, D.L., Johnson, R.Y., Moniz, H.A., and Moremen, K.W. (2013) The Lectin Domain of the Polypeptide GalNAc Transferase Family of Glycosyltransferases (ppGalNAc T's) Acts as a Switch Directing Glycopeptide Substrate Glycosylation in an N- or C- Direction, Further Controlling Mucin-Type O-Glycosylation. J. Biol. Chem. 288, 19900-14 [PMID 23689369] [PMC3707691]
77. Gasimli L, Stansfield HE, Nairn AV, Liu H, Paluh JL, Yang B, Dordick JS, Moremen KW, Linhardt RJ. (2013) Structural remodeling of proteoglycans upon retinoic acid-induced differentiation of NCCIT cells. Glycoconj J. 30, 497-510 [PMID 23053635] [PMC3556377]
2012
76. Nairn, A.V., Aoki, K., dela Rosa, M., Porterfield, M., Lim, J.-M., Kulik, M., Pierce, J.M. Wells, L., Dalton, S., Tiemeyer, M., and Moremen, K.W. (2012) Regulation of glycan structures in murine embryonic stem cells: combined transcript profiling of glycan-related genes and glycan structural analysis. J. Biol. Chem. 287, 37835-56. [PMID 22988249] [PMC3488057]
75. Lamanna, W.C., Lawrence, R., Sarrazin, S., Lameda-Diaz, C., Gordts, P.L.S.M., Moremen, K.W., and Esko, J.D. (2012) A Genetic Model of Substrate Reduction Therapy for Mucopolysaccharidosis. J Biol Chem. 287, 36283-90. [PMID 22952226] [ PMC3476295]
74. Condac, E., Strachan, H., Gutierrez-Sanchez, G., Giese, C., Heiss, C., Johnson, D., Azadi, P., Bergman, C., Orlando, R., Esmon, C.T., Harenberg, J., Moremen, K.W., and Wang, L. (2012) The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin`s anticoagulant activity Glycobiology, 22, 1183-92. [PMID 22641771] [PMC3406619]
73 Guo H, Nairn A, dela Rosa M, Nagy T, Zhao S, Moremen K, Pierce M. (2012) Transcriptional regulation of the protocadherin ? cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching. J Biol Chem. 287, 24941-24954 [PMID 22665489] [PMC3408139]
72. Zhao, P., Nairn, A.V., Hester, S., Moremen, K.W., O'Regan, R.M., Oprea, G., Wells, L., Pierce, M., Abbott, K.L. (2012) Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem. 287, 25230-25240. [PMID 22654114] [PMC3408190]
71. Kraushaar, D.C., Rai, S., Condac, E, Nairn, A., Zhang, S., Yamaguchi, Y., Moremen, K.W., Dalton. S., Wang, L. (2012) Heparan sulfate facilitates FGF and BMP signaling to drive mesoderm differentiation of mouse embryonic stem cells. J. Biol. Chem. 287, 22691-700 [PMID 22556407] [PMC3391080]
70 Moremen, K.W., Tiemeyer, M., and Nairn A.V. (2012) Vertebrate protein glycosylation: diversity, synthesis, and function Nat. Rev. Cell Mol. Biol. 13, 448-62 [PMID 22722607] [PMC3934011]
69. Barb, A.W., Meng, L., Gao, Z., Johnson, R.W., Moremen, K.W., and Prestegard, J.H. (2012) NMR Characterization of Immunoglobulin G Fc Glycan Motion on Enzymatic Sialylation. Biochemistry, 51, 4618-26. [PMID 22574931] [PMC3447994]
68. Petrey, A.C., Flanagan-Steet, H., Johnson, S., Fan, X., dela Rosa, M., Haskins, M. E., Nairn, A. V., Moremen, K. W., and Steet, R. (2012) Excessive Activity of Cathepsin K is Associated with the Cartilage Defects in a Zebrafish Model for Mucolipidosis II. Dis. Model. Mech. 5, 177-90. [PMID 22046029] [PMC3291639]
2011
67. Pan, S., Wang, S., Utama, B., Huang, L., Blok, N., Estes, M.K., Moremen, K.W., and Sifers, R.N. (2011) Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system Mol. Biol. Cell, 22, 2810-22. [PMID 21697506] [PMC3154878]
66. Rafiq, M.A., Kuss, A. W., Puettmann, L., Noor, A., Ramiah, A., Ali, G., Hu, H., Kerio, N. A., Xiang, Y., Garshasbi, M., Khan, M. A., Ishak, G. E., Weksberg, R., Ullmann, R., Tzschach, A., Kahrizi, K., Mahmood, K., Naeem, F., Ayub, M., Moremen, K.W., John B. Vincent, J.B., Ropers, H.H., Ansar, M., Najmabadi, H. (2011) Mutations in the ?1,2-mannosidase gene, MAN1B1, cause autosomal recessive intellectual disability Amer. J. Human Genet. 15, 176-82. [PMID 21763484] [PMC3135808]
2010
65. Zhu, Y., Suits, M.D.L., Thompson, A.J., Chavan, S., Dinev, K., Dumon, C., Smith, N., Moremen, K., Xiang, Y., Siriwardena, A., Williams, S.J., Gilbert, H.J. and Davies, G.J. (2010) Mechanistic insights into a Ca2+-dependent family of ?-mannosidases in a human gut symbiont. Nat. Chem Biol. 6, 125-132 [PMID 20081828] [PMC3942423]
64. Nairn, A.V. dela Rosa, M., and Moremen, K.W. (2010) Transcript Analysis in Stem Cells. Meth. Enzymol. 479, 73-91. [PMID 20816160] [PMC3104320]
63. Park, H., Haynes, C.A., Nairn, A.V., Nash, R., Dalton, S., Moremen, K.W., and Merrill, A.H. Jr. (2009) Transcript profiling and lipidomic analysis of ceramide subspecies in mouse embryonic stem cells and embryoid bodies. J. Lipid Res. 51, 480-489 [PMID 19786568] [PMC2817578]
2009
62. Liu, S., Meng, L. Moremen, K.W., and Prestegard, J.H. (2009) NMR structural characterization of substrates bound to the ?-2,6-sialyltransferase, ST6Gal-I. Biochemistry, 48, 11211-11219 [PMID19845399] [PMC2790006]
61 Orlando, R., Lim, J., Atwood, J., Angel, P., Fang, M., Aoki, K., Alvarez-Manilla, G., Moremen, K., York, W., Tiemeyer, M., Pierce, M., Dalton, S., Wells, L. (2009) IDAWG: Metabolic incorporation of stable isotope labels for quantitative glycomics of cultured cells. J. Proteome Res., 8, 3816-23. [PMID 19449840] [PMC4141490]
60. Termine, D.J., Moremen, K.W., and Sifers, R.N. (2009) The mammalian UPR boosts glycoprotein ERAD by suppressing the down-regulation of ER mannosidase I. J. Cell Sci. 122, 976-84. [PMID 19258393] [PMC2720930]
2008
59. Macnaughtan, M.A., Tian, F., Liu, S., Meng, L., Park, S., Azadi, P., Moremen, K.W., and Prestegard, J.H. (2008) 13C-Sialic Acid Labeling of Glycans on Glycoproteins Using ST6Gal-I J. Am. Chem. Soc. 130, 11864-11865 [PMID 18700760] [PMC2640832]
58. Abbott, K.L., Nairn, A.V., Horton, M.B., McDonald, J.F., Moremen, K.W., Dinulescu, D.M., Pierce, M. (2008) Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics, 8, 3210-3220. [PMID 18690643] [PMC3970323]
57. Zhong, W.E., Kuntz, D.A., Ember, B., Singh, H., Moremen, K.W., Rose, D.R., and Boons G.-J. (2008) Probing the substrate specificity of Golgi ?-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J. Am. Chem. Soc. 130, 8975-8983. [PMID 18558690] [PMC3982601]
56. Nairn A.V., York, W.S., Harris, K., Hall, E.M., Pierce, J.M. and Moremen, K.W. (2008) Regulation of glycan structures in animal tissues: transcript profiling of glycan-related genes. J. Biol. Chem., 283, 17298-17313. [PMID 18411279] [PMC2427342]
55. Guo, H.-B., Nairn, A., Harris, K., Randolph, M., Alvarez-Manilla, G., Moremen, K.W., and Pierce, M. (2008) Loss of expression of N-acetylglucosaminyltransferase Va results in altered gene expression of glycosyltransferases and galectins, FEBS Lett., 582, 527-535. [PMID 18230362] [PMC3971636]
2007
54. Nairn, A. V., Kinoshita-Toyoda, A., Toyoda, H., Xie, J., Harris, K., Dalton, S., Kulik, M., Pierce, J.M., Toida, T., Moremen, K.W., and Linhardt, R. J. (2007) Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation, J. Proteome. Res. 6, 4374-4387 [PMID 17915907] [PMC3973744]
53. Liu, S., Venot, A., Meng, L., Tian, F., Moremen, K.W., Boons, G.-J., and Prestegard, J.H. (2007) Spin-Labeled Analogs of CMP-NeuAc as NMR probes of the ?-2,6-sialyltransferase ST6Gal ?. Chem. Biol., 14, 409-418 [PMID 17462576] [PMC3968682]
52. Wu Y., Termine D.J., Swulius M.T., Moremen K.W., Sifers R.N. (2007) Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis. J. Biol. Chem. 282, 4841-4849 [PMID 17166854] [PMC3969733]
2006
51. Akama, T.O., Nakagawa, H., Wong, N.-K. Sutton-Smith, M., Dell, A., Nakayama, J., Nishimura, S., Pai, A., Moremen, K.W., Marth, J.D., and Fukuda, M.N. (2006) Essential and mutually compensatory roles of ?-mannosidase II and ?-mannosidase IIx in N-glycan processing in vivo in mice. Proc. Natl. Acad. Sci. U.S.A. 103, 8983-8988 [PMID 16754854] [PMC1474017]
50. Moremen, K.W. and Molinari, M. (2006) N-linked glycan recognition and processing: the molecular basis of ER quality control Curr. Opinion Structural Biol. 16, 592-599 [PMID 16938451]
49. Mast, S.W. and Moremen, K.W. (2006) Family 47 ?-Mannosidases in N-glycan processing Meth. Enzymol. 415, 31-45. [PMID 17116466] [PMC3964790]
2005
48. Herring, K.W., Karaveg, K., Moremen, K.W., and Pearson, W.H. (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum ?-mannosidase I J. Org. Chem. 70, 9892-9904. [PMID 16292820]
47. Park, C., Meng, L. Stanton, L.H., Collins, R.E., Mast, S. W., Yi, X., Strachan, H., and Moremen, K.W. (2005) Characterization of a human core-specific lysosomal ?1,6-mannosidase involved in N-glycan catabolism. J. Biol Chem. 280, 37204-37216 [PMID 16115860] [PMC1351102]
46. Karaveg, K. and Moremen, K.W. (2005) Energetics of substrate binding and catalysis by Class 1 (glycosylhydrolase family 47) ?-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol Chem. 280, 29837-29848 [PMID15713668]
45. Siriwardena, A., Strachan, H., El-Daher, S., Way, G., Winchester, B., Glushka. J., Moremen, K., Boons, G.J. (2005) Potent and Selective Inhibition of Class II ?-D-Mannosidase Activity by a Bicyclic Sulfonium Salt. Chembiochem. 6, 845-848.
44. Karaveg, K., Siriwardena, A., Tempel, W., Liu, Z.-J., Glushka, J., Wang, B.-C., and Moremen, K.W. (2005) Mechanism of Class 1 (glycosylhydrolase family 47) ?-mannosidases involved in N-glycan processing and endoplasmic reticulum quality control. J. Biol Chem. 280, 16197-16207 [PMID15713668]
43. Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N., and Moremen, K.W. (2005) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in the ER-associated degradation of glycoproteins. Glycobiology, 15, 421-436
2004
42. Li, B., Kawatkar, S.P., George, S., Strachan, H., Woods, R.J., Siriwardena, A., Moremen, K.W., Boons, G.J. (2004) Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem. 5, 1220-7
41. Lee, J.-K. Baum, L.G., Moremen, K., Pierce, M. (2004) The X-lectins: A new family with homology to the Xenopus laevis oocyte lectin XL-35 Glycoconj. J. 21, 443-450.
40 Tempel, W., Karaveg, K., Lui, Z.J., Rose, J., Wang, B.-C. and Moremen, K.W. (2004) Structure of mouse Golgi ?-mannosidase IA reveals the molecular basis for substrate specificity among Class I (family 47 glycosyl hydrolase) a1,2-mannosidases. J. Biol. Chem. 279, 29774-29786
2003
39. Wu, Y., Swulius, M.T., Moremen, K.W., Sifers, R.N. (2003) Elucidation of the molecular logic that preferentially targets misfolded ?1-antitrypsin for intracellular degradation. Proc. Natl. Acad. Sci. U.S.A. 100, 8229-8234
2002
38. Cabral, C.M., Liu, Y., Moremen, K.W., and Sifers, R.N. (2002) Organizational diversity among distinct glycoprotein ER-associated degradation programs Mol. Biol. Cell 13, 2639-2650
37. Moremen, K.W. (2002) Golgi ?-Mannosidase II deficiency in vertebrate systems: implications for Asparagine-linked oligosaccharide processing in mammals Biochim. Biophys. Acta, 1573, 225-235.
36. Akama, T.O., Nakagawa, H., Sugihara, K., Narisawa, S., Ohyama, C., Nishimura, S., O'Brien, D.A., Moremen, K.W., Millan, J.L., and Fukuda, M.N. (2002) Germ cell through carbohydrate-mediated interaction with Sertoli cells Science 295, 124-127.
2001
35. Kawar, Z., Karaveg, K., Moremen, K.W., and Jarvis, D.L., (2001) Insect cells encode a Class II ?-mannosidase with unique properties. J. Biol. Chem. 276, 16335-16
34. Oh-eda, M., Nakagawa, H., Akayama, T.O., Lowitz, K., Misago, M., Moremen, K.W., and Fukuda, M.N. (2001) Overexpression of the Golgi-localized enzyme ?-mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl-N-acetylchitobiose to tetramannoseyl-N-acetylchitobiose in the N-glycan processing pathway, Eur. J. Biochem. 268, 1280-1288.
33. Lee, J.-K., Schnee, J., Pang,M., Wolfert, M, Baum, L.G., Moremen, K.W., Pierce, M. (2001) Human homologs of the Xenopus oocyte cortical granule lectin XL35. Glycobiology 11, 65-73.
32. Rivera-Marrero, C.A., Ritzenthaler, J.D., Roman, J., Moremen, K.W. (2001) Molecular cloning and expression of an ?-mannosidase gene in Mycobacterium tuberculosis. Microb Pathog 30, 9-18
2000
31. Vallee, F., Karaveg, K., Herscovics, A., Moremen, K.W., Howell, P.L. (2000) Structural basis for catalysis and inhibition of N-glycan processing Class 1 ?1,2-mannosidases. J. Biol. Chem., 275, 41287-41298
1999
30. Gonzalez, D. S., Karaveg, K., Vandersall-Nairn, A. S., Lal, A., and Moremen, K. W. (1999) Identification, expression, and characterization of a cDNA encoding human ER mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. J. Biol. Chem. 274, 21375-21386.
29. Igdoural, S.A., Herscovics, A., Lal, A., Moremen, K.W., Morales, C.R., and Hermo, L. (1999) ?-Mannosidases involved in N-glycan processing show cell specificity and distinct subcompartmentalization within the Golgi apparatus of cells in the testis and epididymus. E. Jour. Cell Biology 78, 441-452.
28. Gonzalez, D.S., Kagawa, Y., and Moremen, K.W. (1999) Isolation and Characterization of the Gene Encoding the Mouse Broad Specificity Lysosomal ?-Mannosidase. Biochim. Biophys. Acta 1445, 177-183.
27. Di Virgilio, S, Glushka, J., Moremen, K.W., and Pierce, M. (1999) Enzymatic synthesis of natural and 13C enriched linear poly-N-Acetyllactosamines as ligands for galectin-1. Glycobiology 9, 353-364.
26. Valee, F., Lal, A., Moremen, K.W., and Howell, P.L. (1999) Purification, crystallization and preliminary X-ray crystallographic analysis of recombinant murine Golgi mannosidase IA, a Class I ?-mannosidase involved in Asn-linked oligosaccharide maturation. Acta Crystallog. D55, 571-573
1998
25. Vandersall-Nairn, A., O'Brien, K., Merkle, R. K, Oeltmann, T. N., and Moremen, K.W. (1998) Cloning, expression, purification, and characterization of the acid ?-mannosidase from Trypanosoma cruzi. Glycobiology, 8, 1183-1194
24. Lal, A., Pang, P., Kalelkar, S., Romero, P.A., Herscovics, A., and Moremen, K.W. (1998) Substrate specificities of recombinant murine Golgi ?1,2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing a1,2-mannosidases Glycobiology 8, 981-995
1997
23. Howard, S., Braun, C., McCarter, J., Moremen, K.W., Liao, Y.-F., and Withers, S.G. (1997) Human lysosomal and jack bean ?-mannosidases are retaining glycosidases. Biochem. Biophys. Res. Commun. 238, 896-898
22. Merkle, R.K., Zhang, Y., Ruest, P.J., Lal, A., Liao, Y.-F., and Moremen, K.W. (1997) Cloning, Expression, Purification, and Characterization of the Murine Lysosomal Acid ?-mannosidase. Biochim. Biophys. Acta, 1336, 132-146
21. Chui, D., Oh-eda, M., Liao, Y.-F., Panneerselvam, K., Lal, A., Marek, K.W., Freeze, H.H., Moremen, K.W., Fukuda, M.N., and Marth, J.D. (1997) ?-Mannosidase-II deficiency results in Dyserythropoietic Anemia and unveils an alternate pathway in complex asparagine-linked oligosaccharide biosynthesis, Cell, 90, 157-167.
20. Lee, J. K., Buckhaults, P., Wilkes, C., Teilhet, M., King, M.L., Moremen, K.W., and Pierce, M. (1996) Cloning and expression of a Xenopus laevis oocyte lectin and characterization of its mRNA levels during early development (1996) Glycobiology, 7, 367-372.
19. Jarvis, D.L., Bohlmeyer, D.A., Liao, Y.-F., Lomax, K.K., Merkle, R.K., and Moremen, K.W. (1996) Isolation and characterization of a class II ?-mannosidase cDNA from lepidopteran insect cells, Glycobiology, 7, 113-127
1996
18 Liao, Y.-F., Lal, A., and Moremen, K.W. (1996) Cloning, expression, purification, and characterization of the human broad specificity lysosomal acid ?-mannosidase J. Biol. Chem. 271, 28348-28358
1995
17. Prieto, P., Mukerji, P., Kelder, B., Erney, R., Gonzales, D., Yun, J., Cummings, R., Smith, D. F., Moremen, K. W., Nardelli, C., Pierce, M., and Kopchick, J. J. (1995) Remodeling of mouse milk glycoconjugates by transgenic expression of a human glycosyltransferase. J. Biol. Chem. 270, 29515-29519
16. Misago, M., Liao, Y.-F., Kudo, S., Mattei, M.- G., Moremen, K. W., and Fukuda, M. N. (1995) Molecular cloning and expression of cDNAs encoding human ?-mannosidase II and a novel a-mannosidase IIx isozyme Proc. Natl. Acad. Sci. U.S.A. 92, 11766-11770.
1994
15. Lal, A., Schutzbach, J. S., Forsee, W. T., Neame, P., and Moremen, K.W. (1994) Isolation and expression of a murine and rabbit ?1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. J. Biol. Chem. 269, 9872-9881.
14. Herscovics, A., Schneikert, J., Athanassiadis, A., and Moremen, K.W. (1994) Isolation of a mouse Golgi mannosidase cDNA, member of a gene family conserved from yeast to mammals. J. Biol. Chem. 269, 9864-9871.
13. Oeltman, T., Carter, C., Merkle, R. and Moremen, K. W. (1994) The ?-mannosidase of Trypanosoma cruzi: structure and function. Brazilian J. Med. Biol. Res. 27, 483-488.
12. Moremen, K. W., Trimble, R. B., Herscovics, A. (1994) Glycosidases of the Asparagine-linked Oligosaccharide Processing Pathway. Glycobiology 4, 113-125.
1993
11. Abeijon, C., Yanagisawa, K., Mandon, E.C., Hausler, A., Moremen, K., Herschberg C.B., and Robbins, P.W. (1993) Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J. Cell Biol. 122, 307-323
10. Velasco, A., Moremen, K.W., Hendricks, L. Tulsiani, D. R. P., Touster, O., and Farquhar, M. G., (1993) Cell-type dependent variations in the subcellular distribution of ?-mannosidase IA and II. J. Cell Biol. 122, 39-51.
9. Sasisekharan, R., Bulmer, M., Moremen, K.W., Cooney, C. L., Langer, R. (1993) Cloning and expression of Heparinase I Gene from Flavobacterium heparinum. Proc. Natl. Acad. Sci. U.S.A., 90, 3660-3664.
1991
8. Moremen, K.W. and Robbins, P.W. (1991) Isolation, characterization, and expression of cDNA encoding murine ?-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans J. Cell Biol. 115, 1521-1534.
7. Zuber, C., Roth, J., Mistelli, T., Nakano, A., Moremen, K.W. (1991) DS 28-6, a temperature-sensitive mutant of Chinese hamster ovary cells, expresses the key phenotypic changes associated with Brefeldin A treatment. Proc. Natl. Acad. Sci.U.S.A., 88, 9818-9822.
6. Moremen, K.W., Touster, O. and Robbins, P.W. (1991) Novel purification of the catalytic domain of Golgi mannosidase II: characterization and comparison with the intact enzyme. J. Biol. Chem. 266, 16876-16885.
1990
5. Bischoff, J., Moremen, K.W., and Lodish, H. (1990) Isolation, characterization, and expression of a cDNA encoding the rat liver endoplasmic reticulum ?-mannosidase. J. Biol. Chem. 265, 17110-17117.
4. Fukuda, M. N., Masri, K.A., Dell, A., Luzzato, L., and Moremen, K.W. (1990) Incomplete synthesis of N-glycans in congenital dyserythropoetic anemia II (HEMPAS) caused by a gene defect encoding ?-mannosidase II. Proc. Natl. Acad. Sci. U.S.A. 87, 7443-7447.
1989
3. Moremen, K.W. (1989) Isolation of a rat liver Golgi mannosidase II clone by mixed oligonucleotide-primed amplification of cDNA. Proc. Natl. Acad. Sci. U.S.A. 86, 5276-5280.
1986
2. Moremen, K.W. and Touster, O. (1986) Topology of mannosidase II in rat liver Golgi membranes and release of the catalytic domain by selective proteolysis. J. Biol. Chem. 261, 10945-10951.
1985
1. Moremen, K.W. and Touster, O. (1985) Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells. J. Biol. Chem. 260, 6654-6662.
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